Mechanisms of High-Dose Intravenous Immunoglobulins in Demyelinating Diseases

The therapeutic uses of intravenous immunoglobulins in autoimmune rheumatic diseases.

Immunoglobulins (antibodies) are plasma proteins produced by B cells, which are essential in the defence against bacterial and viral infections. Dysregulation of the immune system can lead to the formation of autoantibodies and subsequent autoimmune disease. Therapy with immunoglobulin was first studied in the late 19th century, when Von Behring and Kitasato showed that serum taken from rabbits...

Clinical utility of intravenous immunoglobulins in autoimmune diseases

Durante los últimos años, la utilización de las inmunoglobulinas endovenosas (Ig ev) se ha extendido desde las inmunodeficiencias primarias, a una serie de entidades clínicas como los procesos infecciosos, las enfermedades neurológicas inflamatorias y las enfermedades autoinmunes. Las Ig ev son una terapia bien tolerada, con pocos efectos adversos, aunque con un elevado coste económico. Aunque ...

Successful application of high dose intravenous immunoglobulins in Sjögren's syndrome associated arthritis.

High dose intravenous immunoglobulin treatment: mechanisms of action.

Intravenous immunoglobulin (IVIg) treatment was introduced as replacement therapy for patients with antibody deficiencies, but evidence suggests that a wide range of immune-mediated conditions could benefit from IVIg. The immunoglobulins are precipitated from human plasma by fractionation methods. In conclusion, the differences in basic fractionation methods and the addition of various modifica...

Intravenous Immunoglobulins in Neurological Diseases: Established and Novel Clinical Applications

Over the last decade, high-dose polyclonal intravenous immunoglobulin (IVIg) is used increasingly in the management of autoimmune conditions of the central and peripheral nervous system. Despite the expanded use of IVIg, the consensus on its optimal use is insufficient. Currently chronic idiopathic demyelinating polyneuropathy (CIDP), Guillain – Barre syndrome (GBS) and multifocal motor neuropa...